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Treatment of cold urticaria
The British Journal of Dermatology
|July 1, 1979
Summary
This study evaluated several drug regimens for severe cold urticaria in one patient. Hydroxyzine combined with cimetidine effectively suppressed erythema, while histamine H1 antagonists reduced wealing significantly.
Area of Science:
- Dermatology
- Allergology
- Pharmacology
Background:
- Acquired cold urticaria is a rare condition causing histamine release upon cold exposure.
- Effective management strategies for severe cases remain an area of clinical interest.
Observation:
- A single patient with severe essential acquired cold urticaria underwent treatment with various drug regimens.
- Regimens assessed included diphenhydramine, cyproheptadine, hydroxyzine, terbutaline, cimetidine, and combination therapies.
Findings:
- All tested drug regimens demonstrated positive effects in managing cold urticaria symptoms.
- Significant therapeutic effects (P = 0.01) were observed for hydroxyzine combined with cimetidine in suppressing erythema.
- Histamine H1 antagonists showed significant efficacy (P = 0.01) in the suppression of wealing.
Implications:
- Combination therapy with hydroxyzine and cimetidine may be a highly effective treatment for cold-induced erythema.
- Histamine H1 antagonists represent a key therapeutic class for controlling cold urticaria wealing.
- Further research is warranted to validate these findings in larger patient cohorts.