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Coagulation activation and hyperviscosity in infection.

S G Richardson, K B Matthews, J K Cruickshank

British Journal of Haematology

|July 1, 1979

Summary

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Infections like malaria and sepsis activate coagulation, unlike benign viral infections or malaria. While hyperviscosity occurs, it doesn't appear to be a primary cause of severe illness.

Area of Science:

Hematology
Infectious Diseases
Pathophysiology

Background:

Coagulation activation and blood viscosity changes are observed in various infections.
Distinguishing these changes in different infectious diseases is crucial for understanding pathogenesis.

Purpose of the Study:

To investigate coagulation activation and whole-blood viscosity in patients with bacterial infections, malaria, and viral infections.
To differentiate the hemostatic profiles associated with different types of infections.

Main Methods:

Serial measurements of coagulation activation markers and whole-blood viscosity.
Study included 37 patients with local/systemic bacterial infection, malaria (benign tertian and malignant tertian), or viral infection.

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Main Results:

Thrombocytopenia was common but only associated with coagulation/fibrinolysis activation in severe infections (septicemia, malignant malaria).
Elevated Factor VIII related antigen in disseminated intravascular coagulation suggested endothelial damage, not just an acute-phase response.
Hyperviscosity correlated with increased fibrinogen in acute infections, but its role in septic shock pathogenesis was not evident.

Conclusions:

Hemostatic changes vary significantly between different infectious diseases.
While hyperviscosity accompanies acute-phase responses, it may not be a primary driver of severe septic shock or other critical illnesses.