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Related Experiment Videos

Multiple births in former oral contraceptive users.

S Harlap

    British Journal of Obstetrics and Gynaecology
    |July 1, 1979
    PubMed
    Summary

    Oral contraceptive use did not significantly alter multiple birth rates. However, underweight former users showed a deficit, while certain pill types and breakthrough pregnancies were linked to increased multiple births.

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    Area of Science:

    • Reproductive Endocrinology
    • Perinatal Epidemiology
    • Human Reproduction

    Background:

    • Oral contraceptives (OCs) are widely used for birth control.
    • The impact of prior OC use on subsequent pregnancy outcomes, including multiple births, requires ongoing investigation.

    Purpose of the Study:

    • To investigate the association between former oral contraceptive use and the incidence of multiple births.
    • To explore potential modifying factors such as body weight and specific OC formulations.

    Main Methods:

    • A cohort study comparing multiple birth rates in former oral contraceptive users and controls.
    • Post-partum interviews were conducted with 2953 former OC users and 13,630 controls.
    • Analysis excluded women treated for anovulation and examined subgroups based on weight and pregnancy type.

    Main Results:

    • Overall multiple birth rates were similar between former OC users (13.5/1000) and controls (14.5/1000).
    • A significant deficit of multiple births was observed in underweight former OC users.
    • Increased multiple births were noted after stopping sequential pills, high-estrogen preparations, and following breakthrough pregnancies.

    Conclusions:

    • While overall rates are similar, specific subgroups of former oral contraceptive users may have altered multiple birth risks.
    • Underweight status appears to be a significant factor in former OC users experiencing fewer multiple births.
    • Findings related to specific pill types and breakthrough pregnancies require further validation due to small sample sizes.

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