Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Succinylcholine drug interactions during electroconvulsive therapy.

L A Marco, P M Randels

    Biological Psychiatry
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neuroleptic malignant syndrome and severe thrombocytopenia: case report and literature review.

    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists·2000
    Same author

    A ketamine-induced rat model of tardive dyskinesia.

    Progress in neurobiology·1992
    Same author

    Effects of MK-801, a non-competitive NMDA antagonist, on linguopharyngeal events in rats.

    Psychopharmacology·1991
    Same author

    Unitary correlates of linguo-pharyngeal events in a dyskinetic rat model.

    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology·1991
    Same author

    Serotonin-containing axon terminals in the hypoglossal nucleus of the rat. An immuno-electronmicroscopic study.

    Brain research bulletin·1989
    Same author

    Effects of clozapine on ketamine-induced linguopharyngeal events in rats.

    European journal of pharmacology·1989
    Same journal

    Neuroimaging of Heterogeneity in Neuropsychiatric Disorders: Toward Disease Progression Modeling.

    Biological psychiatry·2026
    Same journal

    Impact of Transcranial Direct Current Stimulation-Induced Electric Fields on Slowing Cognitive Decline in Older Adults With Mild Cognitive Impairment or Remitted Major Depressive Disorder: An Analysis of the PACt-MD Randomized Clinical Trial.

    Biological psychiatry·2026
    Same journal

    Remembering Jon-Kar Zubieta, M.D., Ph.D.

    Biological psychiatry·2026
    Same journal

    Kappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [<sup>11</sup>C]EKAP PET imaging.

    Biological psychiatry·2026
    Same journal

    From Satiety to Substance Use: Neural Mechanisms of GLP-1 Signaling in Appetite and Reward.

    Biological psychiatry·2026
    Same journal

    Distinct and Shared Molecular Mechanisms Underlie Morphological-Functional Overcoupling and Undercoupling in Major Depressive Disorder.

    Biological psychiatry·2026
    See all related articles

    Electroconvulsive therapy (ECT) has few contraindications, but drug interactions with succinylcholine can cause prolonged paralysis. This risk is heightened in patients on chemotherapy or psychotropic medications, requiring careful management.

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Psychiatry

    Background:

    • Electroconvulsive therapy (ECT) is generally considered safe with minimal absolute contraindications.
    • Succinylcholine, a common muscle relaxant used in ECT, possesses acetylcholine-like effects beyond neuromuscular blockade.
    • An aging population undergoing chemotherapy may increasingly require ECT, raising concerns about drug interactions.

    Purpose of the Study:

    • To highlight potential hazards associated with drug interactions involving succinylcholine during ECT.
    • To inform clinicians about specific drug classes that interact with succinylcholine.
    • To provide guidance on managing these interactions and their complications.

    Main Methods:

    • Review of literature on drug interactions with succinylcholine in the context of ECT.

    Related Experiment Videos

  • Identification of drugs affecting cholinesterase activity, acetylcholine release, or synthesis.
  • Analysis of psychotropic medications known to interact with succinylcholine.

    • Main Results:

    • Drugs inhibiting cholinesterase or acetylcholine synthesis/release can cause prolonged respiratory paralysis with succinylcholine.
    • Certain psychotropic medications present significant risks when combined with succinylcholine.
    • The risk of adverse interactions is increasing due to patient demographics and polypharmacy.

    Conclusions:

    • Clinicians must be aware of potential succinylcholine drug interactions during ECT.
    • Careful consideration of concomitant medications, especially psychotropics and chemotherapy agents, is crucial.
    • Proactive management strategies and preparedness for complications are essential for patient safety in ECT.