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Linkage disequilibrium in subdivided populations.

M Nei, W H Li

    Genetics
    |September 1, 1973
    PubMed
    Summary

    Linkage disequilibrium in subdivided populations can be non-zero even if it is zero within subpopulations. Migration and selection influence the rate of approach to linkage equilibrium.

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    Area of Science:

    • Population genetics
    • Evolutionary biology
    • Quantitative genetics

    Background:

    • Linkage disequilibrium (LD) is a fundamental concept in population genetics.
    • Understanding LD in subdivided populations is crucial for genetic studies.
    • Previous models often assumed random mating or panmixia.

    Purpose of the Study:

    • To mathematically describe linkage disequilibrium in subdivided populations.
    • To investigate the impact of migration and selection on LD.
    • To determine conditions under which permanent LD can arise.

    Main Methods:

    • Theoretical modeling of genetic drift and gene flow.
    • Analysis of covariance between gene frequencies.
    • Mathematical derivation of LD dynamics.

    Main Results:

    • LD in a subdivided population equals the sum of average LD in subpopulations plus covariance of gene frequencies.
    • Migration rate and recombination value determine the rate of approach to equilibrium.
    • Overdominant selection with differing equilibrium frequencies can create permanent LD without epistasis.

    Conclusions:

    • Subdivision itself can generate or maintain LD.
    • Migration can accelerate or retard the approach to LD.
    • Selection can lead to stable LD in subdivided populations, even without epistasis.

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