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Related Experiment Videos

Drug-seeking behavior during methadone maintenance.

B E Jones, J A Prada

    Psychopharmacologia
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Methadone maintenance significantly reduces the rewarding effects of hydromorphone. This opioid substitution therapy decreases the desire for other opiates and related drug-seeking behaviors.

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    Area of Science:

    • Pharmacology
    • Addiction Medicine
    • Neuroscience

    Background:

    • Opioid use disorder presents significant public health challenges.
    • Methadone maintenance therapy is a cornerstone in treating opioid dependence.
    • Understanding methadone's effects on the reinforcing properties of other opioids is crucial for treatment efficacy.

    Purpose of the Study:

    • To investigate the impact of methadone maintenance on the subjective and physiological responses to hydromorphone.
    • To determine the dose-dependent effects of methadone on opioid reinforcement.

    Main Methods:

    • Six subjects received hydromorphone (4 mg i.v.) and placebo multiple times weekly.
    • Subjects underwent methadone maintenance (100 mg p.o. daily) during the study period.

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  • Pupillary changes and self-reported "liking" were measured in response to hydromorphone.

    • Main Results:

    • Hydromorphone's reinforcing effects, indicated by pupillary response and self-reports, decreased to placebo levels at methadone doses around 60 mg daily.
    • Even with continued methadone maintenance (100 mg daily), half the subjects showed reduced responses to hydromorphone over four weeks.

    Conclusions:

    • Methadone maintenance therapy effectively diminishes the reinforcing value of other opioids like hydromorphone.
    • These findings support methadone's role in reducing the motivation for opioid use and associated behaviors.