The effect of disodium 5-ribonucleotide on reproductive function over three generations in the rat

Deitary levels of 0.1, 1.0 and 2.0% disodium 5-ribonucleotide were administered to rats of the CD strain over 3 generations, and the growth and reproductive performance were compared with those of a control group. Treatment did not appear to affect parent animals, as assessed by the incidence of mortality, bodyweight change, food consumption, mating performance, Pregnancy rate, Gestation Peroid, and post-mortem findings. Total litter loss, Litter size, Litter and mean pup weights, pup mortality and the incidence of skeletal or other variants in the offspring were unaffected by treatment at any dosage level. Additional organ weight analysis and skeletal staining of 10 males and 10 females from all groups, and the histological examination of 10 male and 10 females of the control and 2.0% level groups of the third generation did not provide any evidence of effects that could be related to treatment.