Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An improved method for analyzing survival data from combination chemotherapy experiments.

W H Carter, D M Stablein, G L Wampler

    Cancer Research
    |September 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Use of a Modified Gompertz Equation to Predict the Effects of Temperature, pH, and NaCl on the Inactivation of Listeria monocytogenes Scott A Heated in Infant Formula.

    Journal of food protection·2019
    Same author

    Use of a Modified Gompertz Equation to Model Nonlinear Survival Curves for Listeria monocytogenes Scott A.

    Journal of food protection·2019
    Same author

    Adult Acute Lymphoblastic Leukaemia: The Value of Therapy Intensification.

    Leukemia & lymphoma·2016
    Same author

    Improved survival with recent Post-Transplant Lymphoproliferative Disorder (PTLD) in children with kidney transplants.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
    Same author

    Scattering of a light beam from waves at an air-sea interface.

    Applied optics·2010
    Same author

    Resistance of holograms made in dichromated gelatin emulsion to fission neutron damage.

    Applied optics·2010
    Same journal

    CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.

    Cancer research·2026
    Same journal

    A Clinically Integrated Pediatric Patient-Derived Xenograft Program Enables Evaluation of Cohort and Patient-Specific Biology and Therapeutic Strategies.

    Cancer research·2026
    Same journal

    Editor's Note: Heterodimerization of Insulin-like Growth Factor Receptor/Epidermal Growth Factor Receptor and Induction of Survivin Expression Counteract the Antitumor Action of Erlotinib.

    Cancer research·2026
    Same journal

    Editor's Note: Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

    Cancer research·2026
    Same journal

    Retraction: Two Functional Epitopes of Pigment Epithelial-Derived Factor Block Angiogenesis and Induce Differentiation in Prostate Cancer.

    Cancer research·2026
    Same journal

    Editor's Note: Chronic Stress Facilitates Lung Tumorigenesis by Promoting Exocytosis of IGF2 in Lung Epithelial Cells.

    Cancer research·2026
    See all related articles

    This study introduces a novel method for analyzing combination chemotherapy survival data. Researchers found therapeutic synergism, with optimal doses determined by drug interactions, even suggesting zero for one drug.

    Area of Science:

    • Pharmacology
    • Biostatistics
    • Oncology

    Background:

    • Combination chemotherapy is a cornerstone in cancer treatment, but optimizing drug dosages and understanding interactions remains complex.
    • Survival data analysis in chemotherapy experiments requires robust statistical methods to interpret efficacy and toxicity.
    • Response surface methodology offers a framework for analyzing multifactorial experiments, including drug combinations.

    Purpose of the Study:

    • To present a novel statistical method for analyzing survival data from combination chemotherapy experiments.
    • To determine the importance of drug interactions and estimate optimal doses using response surface techniques.
    • To illustrate the application of this method using a specific chemotherapy combination in leukemia models.

    Main Methods:

    Related Experiment Videos

    • Relating survival data to individual drug dosage levels within a combination.
    • Employing response surface techniques to model drug interactions and predict optimal doses.
    • Applying the method to survival data from combination chemotherapy trials in L1210 and P388 leukemia models.

    Main Results:

    • The analysis demonstrated therapeutic synergism between the tested chemotherapeutic agents.
    • Drug interactions significantly influenced survival outcomes and optimal dosage estimations.
    • The predicted optimal dose for mitomycin C was found to be zero across all tested leukemia models.

    Conclusions:

    • The developed method effectively analyzes survival data and quantifies drug interactions in combination chemotherapy.
    • Optimal dosing strategies can be informed by understanding complex drug-drug interactions.
    • The finding of a zero optimal dose for mitomycin C warrants further investigation in specific therapeutic contexts.