Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement system studies in systemic lupus erythematosus (SLE)

P Teisberg

    Acta Medica Scandinavica
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The genetic background of anticipation.

    Journal of the Royal Society of Medicine·1995
    Same author

    Disease caused by expanding genes.

    Journal of internal medicine·1994
    Same author

    Genetics of non-insulin-dependent diabetes mellitus (NIDDM)

    Journal of internal medicine·1993
    Same author

    Linkage and association studies with C8A and C8B RFLPs on chromosome 1.

    Annals of human genetics·1992
    Same author

    Haptoglobin subtypes in Norway and a review of HP subtypes in various populations.

    Human heredity·1992
    Same author

    A BamHI RFLP of the C8A gene.

    Nucleic acids research·1991
    Same journal

    On hereditary, non-hemolytic bilirubinemia.

    Acta medica Scandinavica·2010
    Same journal

    Infections with leukopenia treated with sulfa compounds.

    Acta medica Scandinavica·2010
    Same journal

    A peculiar conduction disturbance, persisting latently after recovery from complete heart block and disclosed only by electrocardiography following exercise.

    Acta medica Scandinavica·2010
    Same journal

    Titration with Weichbrodt's reagent of serum, particularly in the case of gall-liver diseases.

    Acta medica Scandinavica·2010
    Same journal

    Arthralgia due to nervous causes.

    Acta medica Scandinavica·2010
    Same journal

    Auricular standstill.

    Acta medica Scandinavica·2010
    See all related articles

    Systemic lupus erythematosus (SLE) patients often show low complement levels, primarily due to deficient synthesis rather than activation. Complement activation signs appear early, especially in untreated patients.

    Area of Science:

    • Immunology
    • Rheumatology
    • Clinical Medicine

    Background:

    • The complement system plays a crucial role in immune responses.
    • Systemic lupus erythematosus (SLE) is an autoimmune disease associated with complement abnormalities.

    Purpose of the Study:

    • To investigate complement system involvement in SLE patients.
    • To determine the cause of low complement levels in SLE.
    • To identify signs of complement activation in SLE.

    Main Methods:

    • Studied complement component levels (C3, C4, C3 proactivator/properdin factor B) in 16 SLE patients.
    • Assessed circulating C3 conversion products.
    • Correlated complement levels with disease activity and therapy.

    Related Experiment Videos

    Main Results:

    • Low mean values of C4 and C3 were observed in SLE patients.
    • C3 proactivator levels were low in a minority of patients.
    • Circulating C3 conversion products were detected in 4 patients, with no significant difference in complement levels compared to others.
    • Signs of complement activation were evident early in the disease, particularly in patients not on immunosuppressive therapy.

    Conclusions:

    • Low complement levels in SLE are likely caused by deficient synthesis.
    • Complement activation is present early in SLE, especially in untreated individuals.
    • Further research is needed to elucidate the precise role of complement in SLE pathogenesis.