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Bicarbonate hemodialysis using a sorbent regenerative system.

C J Richards, C E Newhouse, R M Freeman

Clinical Nephrology

|June 1, 1979

Summary

This summary is machine-generated.

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Acetate-free hemodialysis is now feasible using a sorbent regenerative system (RED). This method simplifies dialysis and improves patient outcomes by increasing plasma bicarbonate and blood pH.

Area of Science:

Nephrology
Biomedical Engineering

Background:

Concerns exist regarding the use of acetate in dialysate.
Acetate-free hemodialysis offers a potential alternative for patient care.

Purpose of the Study:

To develop and evaluate a simplified method for acetate-free hemodialysis using a sorbent regenerative system (RED).

Main Methods:

Conducted fifteen acetate-free hemodialysis sessions using the RED system on two patients over 4-6 hours.
Utilized a dialysate mixture of sodium bicarbonate (NaHCO3) and chloride salts for infusate cations (K, Ca, Mg).
Performed a 30-minute titration of the sorbent cartridge with bicarbonate dialysate to stabilize bicarbonate levels.

Main Results:

Dialysate sodium (Na) levels decreased during titration but increased during dialysis; chloride (Cl) levels rose throughout.

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Significant increases in plasma bicarbonate were observed by the end of 4 and 6-hour dialysis sessions.

No significant changes in blood oxygen (pO2) or carbon dioxide (pCO2) were noted, but blood pH significantly increased.

Conclusions:

Acetate-free hemodialysis is feasible and relatively easy to perform with the sorbent regenerative system (RED).
This method effectively increases plasma bicarbonate and blood pH without altering blood gases.