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Vitamin D and magnesium absorption in man.

A Hodgkinson, D H Marshall, B E Nordin

    Clinical Science (London, England : 1979)
    |July 1, 1979
    PubMed
    Summary

    Vitamin D significantly boosts calcium absorption and balance in patients with bone disorders. Its effect on magnesium absorption is less pronounced, possibly linked to calcium transport mechanisms.

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    Area of Science:

    • Biochemistry
    • Bone Metabolism
    • Nutritional Science

    Background:

    • Vitamin D is crucial for calcium homeostasis.
    • Disorders of calcium and bone metabolism often involve impaired nutrient absorption.
    • Understanding vitamin D's impact on mineral absorption is vital for therapeutic strategies.

    Purpose of the Study:

    • To investigate the effects of vitamin D and its metabolites on calcium and magnesium absorption.
    • To analyze the influence of vitamin D on mineral balance in patients with bone metabolism disorders.

    Main Methods:

    • Conducted 47 balance studies involving patients with various calcium or bone metabolism disorders.
    • Measured net absorption and balance of calcium and magnesium before and after vitamin D administration.

    Main Results:

    • Vitamin D significantly increased mean net calcium absorption and improved calcium balance.
    • A significant increase in mean net magnesium absorption was observed, but to a lesser extent than calcium.
    • Mean magnesium balance remained unaffected despite increased absorption.

    Conclusions:

    • Vitamin D effectively enhances calcium absorption and balance.
    • The observed modest increase in magnesium absorption may be a secondary effect of vitamin D's primary action on calcium transport.
    • This suggests that vitamin D's influence on magnesium absorption is linked to shared transport pathways for alkaline earth ions.

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