Related Experiment Video

Updated: Aug 10, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

Progression of aortic stenosis

D B Bogart, B L Murphy, B Y Wong

    Chest
    |October 1, 1979
    PubMed

    Insights

    Aortic stenosis progresses in most adults with the condition, leading to a reduced aortic valve area. This progression can occur relatively quickly, within 27-29 months, highlighting the need for monitoring.

    Area of Science:

    • Cardiology
    • Valvular Heart Disease

    Background:

    • Aortic stenosis (AS) is a common valvular heart disease.
    • Understanding the progression of AS in adults without surgical intervention is crucial for patient management.

    Purpose of the Study:

    • To assess the progression of aortic valve stenosis in adult patients with isolated AS who did not undergo aortic valve surgery.

    Main Methods:

    • Retrospective analysis of 11 adult patients with AS.
    • Two cardiac catheterizations were performed on each patient, with a mean interval of 59 months.
    • Measurements included aortic valve area, left ventricular peak systolic pressure, and left ventricular-aortic pressure gradient.

    Main Results:

    • Progressive aortic stenosis was observed in 10 out of 11 patients.
    • A significant decrease in mean aortic valve area (1.2 to 0.7 sq cm) was noted (P < 0.005).
    • Significant increases in left ventricular peak systolic pressure (149 to 199 mm Hg, P < 0.01) and left ventricular-aortic pressure gradient (31 to 75 mm Hg, P < 0.005) were recorded.

    Conclusions:

    • Progressive aortic valve stenosis occurs in adults with isolated AS.
    • A significant reduction in aortic valve area can develop within 27-29 months.
    • Changes in pressure gradients may not always directly correlate with aortic valve area changes due to cardiac output variations.

    More Related Videos

    O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy09:24

    O-Ring Aortic Banding Versus Traditional Transverse Aortic Constriction for Modeling Pressure Overload-Induced Cardiac Hypertrophy

    Published on: October 6, 2022

    A Minimally Invasive Model of Aortic Stenosis in Swine06:51

    A Minimally Invasive Model of Aortic Stenosis in Swine

    Published on: October 20, 2023

    Related Concept Videos

    Mitral Stenosis I: Introduction01:22

    Mitral Stenosis I: Introduction

    Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
    Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

    Mitral Stenosis II: Clinical features and Diagnostic Tests

    Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
    Aortic Regurgitation I: Introduction01:15

    Aortic Regurgitation I: Introduction

    IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
    Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

    Aortic Regurgitation II: Clinical Features and Diagnostic Tests

    Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
    Aortic Regurgitation III: Medical Management01:25

    Aortic Regurgitation III: Medical Management

    Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
    Atherosclerosis I: Introduction01:30

    Atherosclerosis I: Introduction

    Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...