Effects of a new tetrahydroisoquinoline (NC-7197) in experimental cardiogenic shock

Intravenous administration of 1.0 mg/kg of NC-7197 to open and closed-chest anaesthetized dogs immediately after induction of cardiogenic shock by miliary coronary embolization resulted in significant haemodynamic improvement and prolonged survival. These results suggest that NC-7197 may prove to be valuable in the initial management of myocardial infarction complicated by hypotension and shock.