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An experimental evaluation of genetic correlation.

J J Rutledge, E J Eisen, J E Legates

    Genetics
    |December 1, 1973
    PubMed
    Summary

    Antagonistic index selection revealed a stronger genetic correlation between body weight and tail length than expected. This suggests pleiotropic gene effects may significantly hinder aggregate genotype response in animal breeding.

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    QUANTITATIVE GENETICS OF DEVELOPMENT: GENETIC CORRELATIONS AMONG AGE-SPECIFIC TRAIT VALUES AND THE EVOLUTION OF ONTOGENY.

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    Area of Science:

    • Quantitative Genetics
    • Animal Breeding
    • Statistical Genetics

    Background:

    • Estimating realized genetic parameters is crucial for effective animal breeding programs.
    • Understanding genetic correlations between traits informs selection strategies.
    • Paternal half-sib analysis is a standard method for estimating genetic parameters.

    Purpose of the Study:

    • To compare realized heritability and genetic correlations from single-trait and antagonistic index selection with paternal half-sib estimates.
    • To investigate the genetic correlation between six-week body weight and six-week tail length.
    • To evaluate the efficiency of selection as a method for estimating genetic parameters.

    Main Methods:

    • Realized genetic parameters were estimated from single-trait and antagonistic index selection experiments.
    • These estimates were compared with those obtained from paternal half-sib analysis.
    • Replicated selection and control lines were used to estimate sampling variances of realized genetic parameters.

    Main Results:

    • Parameters from single-trait selection closely matched paternal half-sib estimates.
    • The realized genetic correlation between six-week body weight and tail length from antagonistic index selection was significantly higher than other estimates.
    • Standard errors of realized genetic parameters from selection were smaller than paternal half-sib standard errors, indicating selection's efficiency in estimation.

    Conclusions:

    • Antagonistic index selection may result in a stronger realized genetic correlation than predicted by theory.
    • Pleiotropic gene effects might be more potent in retarding aggregate genotype response under antagonistic index selection than currently theorized.
    • Selection is an efficient method for estimating realized genetic parameters, yielding smaller standard errors compared to paternal half-sib methods.

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