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Related Experiment Videos

Long-term cimetidine does not alter serum prolactin.

D L Healy, H G Burger, M G Korman

    Hormone Research
    |January 1, 1979
    PubMed
    Summary
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    Repeated cimetidine use did not alter prolactin levels in men with duodenal ulcers. This suggests cimetidine does not cause gynecomastia through elevated prolactin.

    Area of Science:

    • Pharmacology
    • Endocrinology
    • Gastroenterology

    Background:

    • Cimetidine is a common medication for duodenal ulcers.
    • Gynecomastia (breast enlargement in men) has been anecdotally linked to cimetidine use.
    • The mechanism, potentially involving prolactin, remains unclear.

    Purpose of the Study:

    • To prospectively investigate the effect of chronic cimetidine administration on serum prolactin levels in men with duodenal ulcers.

    Main Methods:

    • 17 men with diagnosed duodenal ulcers participated.
    • Participants received 400 mg of cimetidine twice daily for 12 weeks.
    • Serum prolactin levels were monitored throughout the study period.

    Main Results:

    Related Experiment Videos

  • No significant alteration in mean serum prolactin levels was observed after 12 weeks of cimetidine treatment.
  • Individual prolactin levels remained within normal ranges.

    • Conclusions:

    • Cimetidine ingestion does not lead to hyperprolactinemia (elevated prolactin) in men with duodenal ulcers.
    • Elevated prolactin is unlikely to be the cause of gynecomastia associated with cimetidine use.