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Human platelet reactivity during stressful diagnostic procedures.
Journal of Clinical Pathology
|December 1, 1973
Summary
Cardiac catheterization increases platelet aggregation response to adenosine diphosphate (ADP) due to emotional stress. This heightened platelet activity may contribute to thrombosis and atherosclerosis development.
Area of Science:
- Cardiovascular Medicine
- Hematology
Background:
- Platelet aggregation is crucial in hemostasis and thrombosis.
- Diagnostic procedures can induce physiological stress responses.
Purpose of the Study:
- To investigate the effect of diagnostic procedures on platelet function.
- To explore the role of emotional stress in platelet activation.
Main Methods:
- Assessed platelet aggregation response to adenosine diphosphate (ADP) and glass beads.
- Measured plasma-free fatty acid (FFA) levels.
- Monitored platelet counts.
- Subjects were conscious during cardiac catheterization and diagnostic procedures.
Main Results:
- Platelet aggregation response to ADP increased before and during procedures.
- Platelet response to glass beads decreased before procedures.
- Plasma-free fatty acid (FFA) levels elevated during and after procedures.
- Platelet counts slightly reduced post-procedure.
Conclusions:
- Emotional stress during procedures may increase platelet responsiveness to ADP.
- Elevated platelet activity could be a risk factor for thrombosis and atherosclerosis.