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Interferon induction by the immunomodulating polyanion lambda carrageenan.

E V Turner, G Sonnenfeld

    Infection and Immunity
    |July 1, 1979
    PubMed
    Summary
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    Efficacy and safety of orally/sublingually, intranasally, and intraperitoneally administered recombinant murine interferon in the treatment of murine encephalomyocarditis virus.

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research·2001

    The lambda fraction of carrageenan-induced murine interferon was identified. This interferon fraction demonstrated sensitivity to trypsin and actinomycin D, indicating its protein nature and dependence on cellular transcription.

    Area of Science:

    • Immunology
    • Virology

    Background:

    • Carrageenan is a known inducer of inflammatory responses.
    • Interferons are crucial cytokines in antiviral immunity.
    • Characterization of specific interferon fractions aids in understanding immune mechanisms.

    Purpose of the Study:

    • To characterize the lambda fraction of carrageenan-induced murine interferon.
    • To determine the biochemical properties of this interferon fraction.

    Main Methods:

    • Induction of interferon in murine models using carrageenan.
    • Biochemical assays to assess sensitivity to enzymatic degradation (trypsin).
    • Inhibition assays involving pretreatment of target cells with actinomycin D.

    Main Results:

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    • The lambda fraction of carrageenan-induced murine interferon was isolated and characterized.
    • This interferon fraction exhibited sensitivity to trypsin, suggesting a proteinaceous nature.
    • Pretreatment of target cells with actinomycin D inhibited the interferon's activity, indicating a requirement for cellular transcription.

    Conclusions:

    • The lambda fraction of carrageenan-induced murine interferon is a protein-based molecule.
    • Its activity is dependent on the target cells' transcriptional machinery.