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Related Experiment Videos

Erythrocyte electrolytes in recurrent affective disorders.

N J Birch, J C Goodwin, R P Hullin

    International Pharmacopsychiatry
    |January 1, 1979
    PubMed
    Summary

    This study questions the predictive value of erythrocyte electrolytes and the lithium index in periodic psychoses. Findings suggest active lithium transport in red blood cells, challenging theoretical distribution models.

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    Inorganic pharmacology of lithium.

    Chemical reviews·2001

    Area of Science:

    • Biochemistry
    • Psychiatry
    • Pharmacology

    Background:

    • Erythrocyte electrolytes and the 'lithium index' have been claimed to predict outcomes in periodic psychoses.
    • Previous research suggested theoretical models for lithium distribution across red blood cell membranes.

    Purpose of the Study:

    • To present a modified method for determining erythrocyte electrolytes.
    • To question the predictive value of erythrocyte electrolytes and the lithium index in periodic psychoses.
    • To investigate lithium distribution in patients undergoing treatment.

    Main Methods:

    • A modified method for erythrocyte electrolyte determination was employed.
    • Serial clinical experimental data from patients receiving lithium treatment were collected.
    • A simple method for assessing 'stable state' in long-term lithium treatment was described.

    Main Results:

    • Theoretical predictions of lithium distribution across erythrocyte membranes were not supported by clinical data.
    • Experimental data suggest the presence of active lithium transport in red blood cells.
    • A method to determine the attainment of a 'stable state' during long-term lithium therapy was established.

    Conclusions:

    • The predictive value of erythrocyte electrolytes and the lithium index in periodic psychoses requires further scrutiny.
    • Evidence supports the hypothesis of active lithium transport, rather than passive diffusion, across the red blood cell membrane.
    • The described method aids in monitoring long-term lithium treatment efficacy.

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