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Screening of isoniazid inactivators
Antimicrobial Agents and Chemotherapy
|January 1, 1973
Summary
This study introduces a new method to identify how quickly individuals process isoniazid, a key tuberculosis drug. The technique measures isoniazid and its breakdown product in urine using a simple color test.
Area of Science:
- Pharmacology
- Clinical Chemistry
- Tuberculosis Treatment
Background:
- Isoniazid is a primary drug for tuberculosis treatment.
- Individual differences in isoniazid metabolism affect treatment efficacy and toxicity.
- Accurate phenotyping of isoniazid inactivators is crucial for personalized medicine.
Purpose of the Study:
- To describe a novel method for phenotyping isoniazid inactivators.
- To enable rapid and straightforward assessment of drug metabolism.
Main Methods:
- Administration of a test dose of isoniazid.
- Collection of urine samples post-administration.
- Quantification of free isoniazid and its acetyl derivative using a single colorimetric reaction.
Main Results:
- The described method allows for the simultaneous estimation of free isoniazid and its acetyl derivative.
- The colorimetric reaction provides a basis for phenotyping isoniazid inactivation rates.
Conclusions:
- This colorimetric method offers a practical approach for phenotyping isoniazid inactivators.
- The method facilitates the identification of individuals with rapid or slow isoniazid metabolism.