Related Experiment Video
Updated: Oct 7, 2026

07:15
Invasion of Human Cells by a Bacterial Pathogen
Published on: March 21, 2011
Simplified assay for gentamicin in the presence of other antibiotics
Antimicrobial Agents and Chemotherapy
|May 1, 1973
Abstract:
Gentamicin concentration was estimated by using a clinical isolate of a multiple antibiotic-resistant strain of Staphylococcus epidermidis in an agar well diffusion assay. The presence of clinically attainable concentrations of cephalothin, ampicillin, carbenicillin, clindamycin, or chloramphenicol did not affect the assay.
More Related Videos
Related Concept Videos
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
Estimation of k and VD of Aminoglycosides
Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...

