Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Axenomycins, new cestocidal antibiotics.

C Della Bruna, M L Ricciardi, A Sanfilippo

    Antimicrobial Agents and Chemotherapy
    |June 1, 1973
    PubMed
    Summary

    Axenomycins, new macrolide antibiotics from Streptomyces lisandri, show potent anthelmintic activity against tapeworms. Axenomycin D effectively reduced worm burdens in various animal models via oral administration.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Real World Data from an Italian Outpatient Clinical Setting and from Home Care Assistance of Treatment-Experienced PWH Switching to CAB + RPV Regimen: A Prospective Observational Study.

    AIDS and behavior·2025
    Same author

    Intra-articular hyaluronic acid injections for hip osteoarthritis.

    Journal of biological regulators and homeostatic agents·2018
    Same author

    Allergen sensitizations in southern Italy: a 5-year retrospective study in allergic respiratory patients.

    European annals of allergy and clinical immunology·2013
    Same author

    Safety of intra-articular hip injection of hyaluronic acid products by ultrasound guidance: an open study from ANTIAGE register.

    European review for medical and pharmacological sciences·2013
    Same author

    Arthritis associated with ulcerative colitis: our experience in palermo.

    The Libyan journal of medicine·2011
    Same author

    Hip viscosupplementation under ultra-sound guidance riduces NSAID consumption in symptomatic hip osteoarthritis patients in a long follow-up. Data from Italian registry.

    European review for medical and pharmacological sciences·2011

    Area of Science:

    • Microbiology
    • Parasitology
    • Pharmacology

    Background:

    • Axenomycins represent a novel class of macrolide antibiotics.
    • These compounds are derived from the fermentation of Streptomyces lisandri n.sp.
    • Initial findings indicate potential anthelmintic properties.

    Purpose of the Study:

    • To characterize the anthelmintic activity of axenomycins against cestodes.
    • To evaluate the efficacy of different axenomycin fractions, particularly axenomycin D.
    • To assess the safety and effectiveness of axenomycins in various animal models.

    Main Methods:

    • Isolation of axenomycins from Streptomyces lisandri fermentation broth.
    • Fractionation into components A, B, and D, with focus on axenomycin D.
    • In vivo testing against tapeworm infections (Hymenolepis nana, Taenia pisiformis, Dipylidium caninum, Diphyllobothrium sp., Moniezia expansa, M. benedeni, Avitellina centripunctata) in mice, dogs, and lambs.
    • Administration via the oral route.

    Main Results:

    • Axenomycin D demonstrated high efficacy, achieving 90-100% worm reduction at 5-10 mg/kg.
    • The axenomycin complex showed 50-100% efficacy at 20 mg/kg.
    • The antibiotic was well-tolerated following oral administration.
    • Effective against a range of tapeworm species in experimentally and naturally infected animals.

    Conclusions:

    • Axenomycins, particularly axenomycin D, are effective oral treatments for tapeworm infections.
    • The oral route of administration is feasible and well-tolerated.
    • Axenomycins represent a promising new class of anthelmintic agents.

    Related Experiment Videos