Gas-liquid chromatographic quantitation of phencyclidine.HCl in powders: collaborative study

Six laboratories collaboratively studied a method for the quantitative gas-liquid chromatographic (GLC) determination of phencyclidine.HCl in powders. The phencyclidine.HCl and other water-soluble compounds are dissolved in dilute HCl. A portion of the aqueous solution is made weakly basic with K2HPO4, and the organic-soluble compounds are extracted in CHCl3 for the GLC determination of the phencyclidine.HCl. Eicosane (n-C20) is incorporated in the extracting CHCl3 as an internal standard. The samples collaboratively studied included samples of known phencyclidine.HCl concentration and one sample of unknown purity. Recoveries ranged from 92.1 to 104% and per cent standard deviations from 1.05 to 3.39. The method was adopted as official first action.