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Related Experiment Videos

Possible modulating influence of frontal cortex on nigro-striatal function.

S D Glick, S Greenstein

    British Journal of Pharmacology
    |October 1, 1973
    PubMed
    Summary
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    Unilateral frontal cortex removal in rats causes changes in amphetamine-induced rotation over time. Initially, rats rotate towards the lesion, later towards the intact side, suggesting frontal cortex modulation of the nigro-striatal dopamine system.

    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Neuropharmacology

    Background:

    • The frontal cortex plays a role in motor control and behavioral regulation.
    • Unilateral brain lesions can induce adaptive or maladaptive changes in neural systems.

    Purpose of the Study:

    • To investigate the functional relationship between the frontal cortex and the nigro-striatal dopaminergic system.
    • To characterize the time-dependent behavioral effects of frontal cortex ablation on amphetamine-induced rotation in rats.

    Main Methods:

    • Unilateral ablations of the frontal cortex were performed in rats.
    • Rats were administered (+)-amphetamine at different postoperative intervals (1-30 days).
    • Rotational behavior (ipsilateral or contralateral to the lesion) was measured as an indicator of dopaminergic system activity.

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    Main Results:

    • Rats exhibited ipsilateral rotation (towards the lesion) at early postoperative times (1-7 days).
    • At later times (15-30 days), rotation shifted to the contralateral side (towards the intact hemisphere).
    • Repeated amphetamine administration appeared to attenuate the rate of change in rotational behavior.

    Conclusions:

    • The frontal cortex modulates the activity of the dopaminergic nigro-striatal system.
    • Unilateral frontal cortex ablation induces denervation supersensitivity in the nigro-striatal pathway.
    • The observed time-dependent rotational asymmetry reflects adaptive changes in the brain following cortical injury.