Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basal cell carcinoma--signet ring type. Ultrastructural study.

I S Seo, T F Warner, J B Priest

    Journal of Cutaneous Pathology
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    High level of ATP citrate lyase expression in human and rat pancreatic islets.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2012
    Same author

    18F-labeled resin microspheres as surrogates for 90Y resin microspheres used in the treatment of hepatic tumors: a radiolabeling and PET validation study.

    Physics in medicine and biology·2007
    Same author

    Status analysis and strategic framework for sanitation management in Asia and Africa.

    Water science and technology : a journal of the International Association on Water Pollution Research·2007
    Same author

    Enzymatic hydrolysis of heated whey: iron-binding ability of peptides and antigenic protein fractions.

    Journal of dairy science·2007
    Same author

    Changes in external ear resonance after 3 types of surgery in the patients with chronic otitis media.

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2001
    Same author

    Frequency and CT findings of recurrent disease after lung transplantation.

    Radiology·2001

    Basal cell carcinoma can present with unusual keratinizing cells. These cells show abnormal keratinization, appearing as signet ring cells with distinct cytoplasmic inclusions under electron microscopy.

    Area of Science:

    • Dermatopathology
    • Oncology
    • Cell Biology

    Background:

    • Basal cell carcinoma (BCC) is the most common type of human cancer.
    • Typical BCC exhibits nests of basaloid cells with peripheral palisading.
    • Unusual differentiation patterns can occur in BCC.

    Observation:

    • Light microscopy revealed BCC with atypical keratinizing cells.
    • These cells resembled signet ring cells and contained eosinophilic cytoplasmic inclusions.
    • Ultrastructural examination provided further detail on cellular morphology.

    Findings:

    • The cytoplasmic inclusions were identified as filamentous masses.
    • These masses were surrounded by abundant tonofilaments.
    • This represents a unique form of abnormal individual tumor cell keratinization.

    Related Experiment Videos

    Implications:

    • This finding expands the spectrum of histopathological presentations of basal cell carcinoma.
    • Recognizing this variant is crucial for accurate diagnosis and treatment.
    • Further research may elucidate the specific mechanisms driving this abnormal keratinization.