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Peritoneal clearances.

K D Nolph

    The Journal of Laboratory and Clinical Medicine
    |October 1, 1979
    PubMed
    Summary

    Intermittent peritoneal dialysis may offer limited small solute clearance. Decreased clearance due to disease or interventions may necessitate longer dialysis sessions or switching to continuous ambulatory peritoneal dialysis (CAPD).

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    Area of Science:

    • Nephrology
    • Renal Replacement Therapy

    Background:

    • Intermittent peritoneal dialysis (IPD) is a renal replacement therapy.
    • Adequacy of dialysis is often measured by solute clearance, particularly for small molecules.

    Purpose of the Study:

    • To evaluate the adequacy of intermittent peritoneal dialysis regarding small solute clearance.
    • To discuss factors affecting solute clearance and potential management strategies.

    Main Methods:

    • The study reviews existing data on solute clearance during intermittent peritoneal dialysis.
    • It considers the impact of disease processes and interventions on dialysis efficacy.

    Main Results:

    • Intermittent peritoneal dialysis may provide only borderline adequate clearance of small solutes.
    • Factors such as disease progression can further reduce clearance.
    • Interventions often target larger solutes, with less impact on small molecule removal.

    Conclusions:

    • Reduced small solute clearance during chronic IPD warrants attention.
    • Consideration should be given to increasing IPD duration or initiating continuous ambulatory peritoneal dialysis (CAPD) to ensure adequate toxin removal.

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