Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Detection of circulating immune complexes in pathological human sera.

A H Johnson, J F Mowbray, K A Porter

    Lancet (London, England)
    |April 5, 1975
    PubMed
    Summary

    Researchers detected circulating immune complexes using complement component 1 (C1) binding assays. Some patients had anti-complementary complexes containing nucleic acids, potentially linked to viral antigens and immune-complex vascular disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gender Disparities in Financial Relationships Between Industry and Orthopaedic Surgeons.

    The Journal of bone and joint surgery. American volume·2019
    Same author

    Carbon dioxide assimilation and growth of red spruce (Picea rubens Sarg.) seedlings in response to ozone, precipitation chemistry, and soil type.

    Oecologia·2017
    Same author

    Heavy metals in Jamaican surface soils.

    Environmental geochemistry and health·2013
    Same author

    Acid deposition and forest decline.

    Environmental science & technology·2012
    Same author

    A Dendroctonus bark engraving (Coleoptera: Scolytidae) from a middle Eocene Larix (Coniferales: Pinaceae): early or delayed colonization?

    American journal of botany·2011
    Same author

    A. N. Whitehead's theory of intuition.

    The Journal of general psychology·2010

    Area of Science:

    • Immunology
    • Virology
    • Pathology

    Background:

    • Circulating immune complexes (CICs) play a role in various autoimmune and infectious diseases.
    • Detection of CICs can aid in disease diagnosis and understanding pathogenesis.
    • The presence of nucleic acids within CICs may indicate viral involvement.

    Purpose of the Study:

    • To describe methods for detecting CICs in patient sera.
    • To investigate the presence of nucleic acid-containing CICs.
    • To explore the association between anti-complementary complexes and vascular disease.

    Main Methods:

    • Two distinct assay methods were employed for CIC detection.
    • Both methods utilized the binding of the first complement component (C1) for detection.

    Related Experiment Videos

  • Analysis focused on identifying CICs containing nucleic acids.

    • Main Results:

    • Circulating immune complexes were detected in patient sera using C1-binding assays.
    • Specific anti-complementary complexes were identified in a subset of patients.
    • These complexes contained nucleic acids, suggesting potential viral antigen presence.

    Conclusions:

    • The developed methods successfully detected CICs, including those with nucleic acid content.
    • The presence of anti-complementary complexes appears to be associated with immune-complex vascular disease.
    • Further investigation into viral antigens within CICs is warranted.