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Eosinophilia in premature infants: relationship to weight gain
Insights
Premature infants often experience eosinophilia, a rise in eosinophil counts. This study found that eosinophilia in premature infants is strongly linked to achieving an anabolic state, crucial for growth.
Area of Science:
- Neonatal Medicine
- Hematology
- Pediatric Physiology
Background:
- Eosinophilia is a common finding in hospitalized premature infants.
- The clinical significance and triggers of eosinophilia in this population require further investigation.
Purpose of the Study:
- To investigate the incidence and characteristics of eosinophilia in premature infants.
- To explore potential associations between eosinophilia and clinical factors, including the establishment of an anabolic state.
Main Methods:
- Serial eosinophil counts were performed on 38 hospitalized premature infants (gestational age 27-35 weeks).
- Data on gestational age, birth stress, medical interventions, feeding, and weight regain were collected.
- Statistical analysis was used to identify correlations between eosinophilia and clinical parameters.
Main Results:
- 76% of infants exhibited absolute eosinophilia (greater than 700/mm3).
- Eosinophilia onset averaged day 19, peaking within a week and lasting approximately 16 days.
- A strong correlation (r=0.86) was observed between peak eosinophilia and birthweight regain, suggesting an anabolic state.
Conclusions:
- Eosinophilia is prevalent in premature infants and appears to be a marker for the establishment of an anabolic state.
- No association was found between eosinophilia and gestational age, birth stress, or feeding methods.
- Further research is warranted to elucidate the precise mechanisms linking eosinophilia to anabolism in neonates.
Abstract:
Serial eosinophil counts were determined in 38 hospitalized, appropriately grown premature infants whose gestational ages ranged from 27 to 35 weeks. Absolute eosinophilia (greater than 700/mm3) was documented in 76% (29/38). Eosinophilia was mild (700 to 999/mm3) in 9, moderate (1,000 to 2,999/mm3) in 17, and marked (greater than or equal to 3,000/mm3) in 3 patients. The average time of onset was day 19. Peak eosinophilia was usually seen within one week of onset and lasted an average of 16 days. A consistent relationship (r = 0.86) was found between the day of peak eosinophilia (mean = day 27) and the day on which birthweight was regained (mean = day 22). No association was apparent between the occurrence or degree of eosinophilia and gestational age, birth stress, presence of umbilical catheter, parenteral alimentation solution, and time of beginning or type or oral feeds. The data suggest that eosinophilia is strongly associated with the establishment of an anabolic state.