Synthesis of substituted 2-aminopyrrole analogs of lidocaine II

The synthesis and local anesthetic and antiarrhythmic properties of eight substituted 2-diethylaminoacetamido-3-carbamyl-4-methylpyrroles are described. Three compounds showed significant local anesthetic activity by the guinea pig wheal test, and four showed antiarrhythmic activity against chloroform-induced ventricular arrhythmias in mice.