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Related Experiment Videos

Bacteriuria with intestinal loop urinary diversion in children.

W W Stewart, A S Cass, J M Matsen

    The Journal of Urology
    |October 1, 1979
    PubMed
    Summary
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    Urinary diversion in children with open ureterointestinal anastomoses did not hinder growth. Long-term antibiotic use showed no significant benefits for preventing bacteriuria or improving renal function.

    Area of Science:

    • Pediatric Urology
    • Surgical Outcomes
    • Infectious Disease Management

    Background:

    • Intestinal loop urinary diversion with open ureterointestinal anastomoses is a surgical technique used in pediatric patients.
    • Concerns exist regarding the impact of refluxing anastomoses on renal growth and the long-term efficacy of antibiotic prophylaxis for bacteriuria.

    Purpose of the Study:

    • To evaluate the long-term effects of urinary diversion with open ureterointestinal anastomoses on renal and body growth in children.
    • To compare the efficacy of long-term sulfamethoxazole and nitrofurantoin versus no treatment in preventing or treating bacteriuria and maintaining renal function.

    Main Methods:

    • A cohort of 44 children undergoing intestinal loop urinary diversion with open ureterointestinal anastomoses was followed for an average of 55.2 months.

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  • Renal and body growth, stoma status, loop residual, renal function, and serum electrolytes were monitored.
  • A comparative analysis was performed between long-term antibiotic prophylaxis (sulfamethoxazole or nitrofurantoin) and no treatment.

    • Main Results:

    • Normal renal and body growth was observed in children with urinary diversion and open ureterointestinal anastomoses.
    • No statistically significant differences were found in stoma, loop residual, renal function, or serum electrolytes between the treatment groups.
    • Long-term antibiotic use did not demonstrate a significant advantage in preventing or treating bacteriuria compared to no treatment.

    Conclusions:

    • Urinary diversion with open ureterointestinal anastomoses is compatible with normal growth in children.
    • Long-term antibiotic prophylaxis with sulfamethoxazole or nitrofurantoin does not offer significant benefits in managing bacteriuria or preserving renal function in this patient population.