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Related Experiment Videos

Infectious mononucleosis: model for self-limiting lymphoproliferation.

R L Carter

    Lancet (London, England)
    |April 12, 1975
    PubMed
    Summary

    Infectious mononucleosis (I.M.) involves extensive lymphoproliferation controlled by immune responses. Host T cells become cytotoxic to Epstein-Barr virus-infected B cells, limiting the disease.

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    Area of Science:

    • Immunology
    • Virology
    • Cell Biology

    Background:

    • Infectious mononucleosis (I.M.) is characterized by significant lymphoproliferation.
    • The Epstein-Barr virus (EBV) is the primary causative agent of I.M.

    Purpose of the Study:

    • To summarize evidence for lymphoproliferation in I.M.
    • To discuss mechanisms controlling lymphoproliferative activity in I.M.
    • To review the host immune response to EBV infection.

    Main Methods:

    • Review of existing evidence on I.M. pathogenesis.
    • Analysis of humoral and cellular immune responses.
    • Discussion of T-cell and B-cell interactions in EBV infection.

    Main Results:

    • Host immune responses, including antibodies and cellular immunity, limit lymphoproliferation.
    • EBV preferentially infects B lymphocytes, altering their antigens.
    • T cells mount a cytotoxic response against EBV-infected B cells.

    Conclusions:

    • The predominant T-cell response is crucial in controlling I.M.
    • Heterophil antibodies may contribute to the self-limiting nature of I.M.
    • I.M. is generally self-limiting, with a limited association with irreversible lymphoproliferative disorders.

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