A study of patients with erythema nondosum leprosum syndrome

25 cases of Erythema Nodosum Leprosum (ENL) Syndrome have been clinically evaluated. Majority patients (84%) were males in the middle age group. Fever (56%), arthralgia (100%) and neuritic pains (100%) were common presenting constitutional symptoms. ENL was not related to DDS therapy or to any precipitating factors. Severity of reaction graded by clinical scoring was well correlated with fibrinolytic activity. Fibrinolytic activity was found decreased in all the cases. The decreases in fibrinolytic activity was more so pronounced in patients having higher clinical scorings.