Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fitzgerald factor: a hitherto unrecognised coagulation factor.

R Waldmann, J P Abraham, J W Rebuck

    Lancet (London, England)
    |April 26, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Decreased superoxide dismutase activity in erythrocyte in Parkinson's disease.

    The Japanese journal of psychiatry and neurology·1992
    Same author

    [Application of ultrasonography in chest diseases--usefulness of ultrasonography and physiologic evaluation of low pressure vascular system].

    Nihon Kyobu Shikkan Gakkai zasshi·1992
    Same author

    Recent advances in the study of hepatocellular carcinoma.

    The Keio journal of medicine·1992
    Same author

    Evaluation of cor pulmonale on a modified short-axis section of the heart by magnetic resonance imaging.

    The American review of respiratory disease·1992
    Same author

    Impaired secretion of the elongated mutant of protein C (protein C-Nagoya). Molecular and cellular basis for hereditary protein C deficiency.

    The Journal of clinical investigation·1992
    Same author

    A 50-year-old man with ulcerative colitis and severe anemia.

    The Keio journal of medicine·1992
    Same journal

    Inherited retinal degenerations: clinical phenotypes and emerging therapies.

    Lancet (London, England)·2026
    Same journal

    Documenting hospice care.

    Lancet (London, England)·2026
    Same journal

    After the wood chipper.

    Lancet (London, England)·2026
    Same journal

    Assisted dying and the silencing of medicine's next generation.

    Lancet (London, England)·2026
    Same journal

    Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

    Lancet (London, England)·2026
    Same journal

    Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

    Lancet (London, England)·2026
    See all related articles

    A novel asymptomatic coagulation factor deficiency was identified in a 71-year-old male. This factor impacts the intrinsic coagulation pathway and Hageman factor-mediated reactions, alongside an atypical inflammatory response.

    Area of Science:

    • Hematology
    • Coagulation science
    • Immunology

    Background:

    • Coagulation factor deficiencies can lead to bleeding disorders.
    • The intrinsic coagulation pathway and Hageman factor play crucial roles in hemostasis and inflammation.
    • Asymptomatic deficiencies may present unique clinical and biological characteristics.

    Purpose of the Study:

    • To report a newly recognized asymptomatic coagulation factor deficiency.
    • To investigate the role of this factor in the intrinsic coagulation pathway.
    • To explore its involvement in Hageman factor-mediated reactions and inflammatory processes.

    Main Methods:

    • Case report of a 71-year-old male patient.
    • Coagulation factor analysis to identify the deficiency.

    Related Experiment Videos

  • Skin-window technique to assess cellular inflammatory response.

    • Main Results:

    • Identification of a previously unrecognized coagulation factor deficiency.
    • Evidence suggesting the factor's role in the early intrinsic coagulation pathway.
    • Association with Hageman factor-mediated biological reactions.
    • Observation of an atypical cellular inflammatory response via the skin-window technique.

    Conclusions:

    • A new asymptomatic coagulation factor deficiency has been identified.
    • The factor is implicated in early intrinsic coagulation and Hageman factor pathways.
    • The deficiency is linked to an unusual inflammatory cellular response.