Blood sugar response to glucagon in migraine

The hyperglycaemic response to intramuscular glucagon was studied in 19 migraine subjects and 17 matched controls. Venous blood sugar 30 minutes after the injection, and the maximum rise from fasting levels, were significantly reduced in migraine subjects. This diminished sensitivity to the hyperglycaemic action of glucagon may be at least one factor in the hypoglycaemia unresponsiveness shown in migraine.