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Related Experiment Videos

Immunity in experimental T-mycoplasma mastitis.

C J Howard, R N Gourlay, J Brownlie

    Infection and Immunity
    |February 1, 1974
    PubMed
    Summary

    Cows infected with T-mycoplasma develop immunity to reinfection within the udder. However, this immunity is strain-specific and depends on the ability to resolve the initial infection without antibiotics.

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    New and emerging pathogens in canine infectious respiratory disease.

    Veterinary pathology·2013

    Area of Science:

    • Veterinary Immunology
    • Bovine Mastitis Research
    • Mycoplasma Infections in Cattle

    Background:

    • T-mycoplasma causes mastitis in cattle, impacting udder health.
    • Understanding immunity following T-mycoplasma infection is crucial for disease control.

    Purpose of the Study:

    • To investigate the nature and specificity of immunity to T-mycoplasma reinfection in the bovine mammary gland.
    • To determine if the ability to resolve initial infection influences subsequent immunity.

    Main Methods:

    • Experimental infection of the bovine mammary gland with T-mycoplasma strains.
    • Assessing immunity to homologous and heterologous T-mycoplasma strains post-infection.
    • Correlating resolution of primary infection (with or without antibiotics) with immune response.

    Main Results:

    • Homologous T-mycoplasma reinfection immunity was demonstrated in the bovine mammary gland, generalized throughout the udder.
    • Immunity was not absolute against serologically distinct T-mycoplasma strains.
    • Cows resolving initial infections without antibiotics showed immunity to homologous challenge, unlike some that required antibiotic treatment.

    Conclusions:

    • Immunity to T-mycoplasma reinfection in cattle is strain-specific and localized to the udder.
    • Resolution of primary infection without antibiotic intervention is a key factor in developing robust homologous immunity.

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