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Related Experiment Videos

Variations in serum complement following inulin infusion in man.

A R Nissenson, L E Rice, E V Potter

    Nephron
    |January 1, 1979
    PubMed
    Summary

    Intravenous inulin infusions in healthy volunteers significantly decreased complement levels, particularly beta IC globulin and total hemolytic activity. This complement activation, dose-dependent and linked to the alternate pathway, occurred at inulin levels above 26 mg%.

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    Area of Science:

    • Immunology
    • Nephrology

    Background:

    • The complement system is crucial for immune response.
    • Inulin clearance is a standard measure of kidney function.

    Purpose of the Study:

    • To investigate the effect of intravenous inulin infusions on complement levels in healthy humans.
    • To determine if inulin affects coagulation parameters.

    Main Methods:

    • 12 healthy volunteers received intravenous infusions of inulin or saline.
    • Complement levels (beta IC globulin, total hemolytic activity, C4) were measured.
    • Inulin clearances and coagulation markers (fibrinogen, fibrin degradation products) were assessed.

    Main Results:

    • Inulin infusion, but not saline, caused significant decreases in beta IC globulin and total hemolytic complement activity.

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  • These effects were observed at steady-state inulin levels > 26 mg%, indicating a dose-dependent response.
  • No significant changes in coagulation markers or C4 levels were noted.

    • Conclusions:

    • Inulin infusion activates the complement system, likely via the alternate pathway.
    • The observed effects are dose-dependent and not associated with increased coagulation.