[AMP-aminohydrolase of skeletal muscles in muscular diseases]

Determinations of AMP-aminohydrolase activity were done in muscles in 34 cases of different neuromuscular diseases, and 30 subjects without skeletal muscle changes. In the group of patients Duchenne's progressive dystrophy accounted for 10 cases, the remaining patients had limb-girdle dystrophy, polymyositis, myotonia, collagen diseases, myopathies of nuclear aetiology, and neurogenic muscle disease. The highest fall in the activity of the enzyme was observed in Duchenne's dystrophy. The authors discuss the possible mechanism of development of these abnormalities.