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Time course of serotonin-induced vasoconstriction.

G D Silverberg, G Ross, S D Corbin

    Neurosurgery
    |June 1, 1979
    PubMed
    Summary

    Canine cerebral arteries show reduced serotonin-induced constriction over time. Extracellular potassium enhances serotonin

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Cardiovascular Research

    Background:

    • Serotonin is a potent vasoconstrictor in cerebral arteries.
    • Understanding the dynamics of serotonin-induced vasoconstriction is crucial for managing cerebrovascular conditions.

    Purpose of the Study:

    • To investigate the time-dependent effects of serotonin on canine cerebral arterial segments.
    • To explore the influence of extracellular ions and verapamil on serotonin-induced vasoconstriction.

    Main Methods:

    • Tissue bath experiments on canine basilar and middle cerebral arteries.
    • Administration of varying doses of serotonin.
    • Assessment of contractile responses and 'escape' phenomenon.
    • Evaluation of the effects of verapamil, potassium, barium, and tetraethylammonium.

    Main Results:

    • Canine cerebral arteries exhibited an 'escape' from serotonin's vasoconstrictor effects, with basilar segments showing faster escape than middle cerebral segments.
    • Serotonin induced dose-dependent contractions: low doses caused sustained contraction, while higher doses elicited a phasic response.
    • Verapamil inhibited the phasic component but not the sustained contraction.
    • Increased extracellular K+, Ba++, and tetraethylammonium enhanced low-dose serotonin contractions and inhibited escape.

    Conclusions:

    • Cerebral arteries can develop tolerance to serotonin's vasoconstrictor effects.
    • Extracellular potassium may play a significant role in potentiating and prolonging vasoconstriction induced by vasoactive amines.
    • These findings may have implications for understanding prolonged vascular narrowing in subarachnoid hemorrhage.

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