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Interaction between doxycycline and barbiturates.

P J Neuvonen, O Penttilä

    British Medical Journal
    |March 23, 1974
    PubMed
    Summary
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    Phenobarbitone and other barbiturates significantly shorten the half-life of doxycycline, potentially reducing its effectiveness. Caution is advised when combining these drugs to maintain adequate antibiotic levels.

    Area of Science:

    • Pharmacology
    • Drug Interactions
    • Clinical Therapeutics

    Background:

    • Doxycycline is a widely used antibiotic.
    • Barbiturates are known to induce drug-metabolizing enzymes.
    • Potential interactions between antibiotics and enzyme inducers require investigation.

    Purpose of the Study:

    • To investigate the effect of phenobarbitone on the half-life of doxycycline.
    • To assess the impact of continuous barbiturate therapy on doxycycline pharmacokinetics.

    Main Methods:

    • A cross-over study design was employed.
    • Five hospitalized patients received 10 days of phenobarbitone treatment.
    • Five patients on continuous barbiturate therapy were also included.

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    Main Results:

    • Phenobarbitone significantly shortened the half-life of doxycycline.
    • Continuous barbiturate therapy resulted in an even shorter doxycycline half-life.
    • This indicates accelerated doxycycline metabolism.

    Conclusions:

    • Concomitant use of barbiturates with doxycycline may lead to subtherapeutic antibiotic concentrations.
    • Drug-metabolizing enzyme inducers should be used cautiously with doxycycline.
    • Clinical monitoring is recommended when combining these agents.