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Related Experiment Videos

Change in oscillatory potential by thioridazine.

S Chotibutr, M Miyata, H Hirosawa

    Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde
    |January 1, 1979
    PubMed
    Summary

    Oral thioridazine causes dose-dependent retinal toxicity in rats, specifically damaging the O2 component of oscillatory potentials (OPs) in electroretinography (ERG). This effect appears permanent, highlighting potential risks of this antipsychotic drug.

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    Area of Science:

    • Ophthalmology
    • Neuroscience
    • Pharmacology

    Background:

    • Thioridazine is an antipsychotic medication with known ocular side effects.
    • Retinal toxicity can lead to irreversible vision loss.
    • Electroretinography (ERG) is a key diagnostic tool for assessing retinal function.

    Purpose of the Study:

    • To investigate the toxic effects of orally administered thioridazine on the retina.
    • To determine the specific retinal components affected by thioridazine exposure.
    • To establish the dose-dependency and permanence of thioridazine-induced retinal changes.

    Main Methods:

    • Male Wistar rats were administered varying doses of thioridazine orally.
    • Electroretinography (ERG) was performed to assess retinal function.

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  • Specific components of the ERG, including oscillatory potentials (OPs), were analyzed.

    • Main Results:

    • A dose-dependent reduction and subsequent disappearance of the O2 component of ERG oscillatory potentials were observed.
    • The minimum effective dose for this toxicity was 3 mg/kg/day for 7 days.
    • A and b waves, along with O1 and O3 oscillatory potentials, remained unaffected.

    Conclusions:

    • Oral thioridazine administration induces specific toxicity to the O2 component of retinal oscillatory potentials.
    • The observed retinal changes appear to be permanent.
    • These findings underscore the potential for thioridazine to cause significant, lasting retinal damage.