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Related Experiment Videos

Focal reflex myoclonus.

G G Sutton, R F Mayer

    Journal of Neurology, Neurosurgery, and Psychiatry
    |February 1, 1974
    PubMed
    Summary
    This summary is machine-generated.

    A patient

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    Area of Science:

    • Neuroscience
    • Clinical Neurology

    Background:

    • Reflex myoclonus can manifest unilaterally.
    • Understanding the neurophysiological underpinnings of reflex myoclonus is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate the neurophysiological characteristics of electrically evoked myoclonus.
    • To elucidate the central nervous system pathways involved in a long loop C reflex.

    Main Methods:

    • Somatosensory evoked response (SER) and C reflex were elicited by median nerve stimulation.
    • Clinical examination and neuroimaging (MRI) were performed to correlate neural dysfunction with symptoms.

    Main Results:

    • Stimulation of the right median nerve induced a large SER and a long loop C reflex in a patient with right-sided reflex myoclonus.

    Related Experiment Videos

  • The patient had a left frontotemporoparietal atrophic vascular lesion and right superior cerebellar peduncle involvement.
  • The findings suggest a 'release effect' leading to increased excitability in the reflex pathway.

    • Conclusions:

    • The proposed pathway for the C reflex involves peripheral nerve, spinal cord dorsal funiculus, thalamus, sensorimotor cortex, corticospinal tract, and anterior horn cell.
    • Unilateral reflex myoclonus may result from central nervous system lesions causing disinhibition and heightened synaptic excitability.