[Specific desensitization of respiratory pollen allergies]

Under the influences of the pollen season and of specific desensitization, the serum IgE concentrations undergo modifications. During the pollen season, the antigenic stimulation induces a rapid synthesis of IgE antibodies which manifest themselves by a post-seasonal pic. The immunotherapy causes an increase of the total and specific IgE during the first few months of treatment. Afterwards the serum levels decrease progressively and after two years of treatment are inferior to the initial values. The same evolution is found in all the subjects, but with variable intensities. Forming parallely are specific blocking antibodies belonging to the IgG class which play, without a doubt, a role in the clinical amelioration obtained during the firsttwo years of treatment.