Evaluation of certain pharmaceuticals with dibromodimethylhydantoin. Part 2: Determination of analgesics

1,3-Dibromodimethylhydantoin (DBH) is a stable dihalogen reagent. It can be used as an analytical reagent for certain analgesics. It gives stoichiometric results by direct titration in acid medium. The end point is detected visually or potentiometrically. Also spectrophotometric titrations have been attempted at 345 nm. In all cases the results of the analysis of the drugs studied either in the pure state or in their dosage forms comply with those given by N-bromo succinimide (NBS) and by the official methods, however this application is distinguished by simplicity and accuracy.