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Exocrine pancreatic function after total gastrectomy.

L Gullo, P L Costa, M Ventrucci

    Scandinavian Journal of Gastroenterology
    |January 1, 1979
    PubMed
    Summary
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    Total gastrectomy impairs exocrine pancreatic function, significantly reducing bicarbonate and lipase secretion. Many patients experience mild to moderate steatorrhoea, indicating digestive issues post-surgery.

    Area of Science:

    • Gastroenterology
    • Digestive Physiology

    Background:

    • Total gastrectomy is a major surgery impacting digestive processes.
    • Exocrine pancreatic function is crucial for nutrient digestion.

    Purpose of the Study:

    • To assess exocrine pancreatic function after total gastrectomy.
    • To quantify the secretion of key pancreatic enzymes and bicarbonate.

    Main Methods:

    • Investigated duodenal secretion of bicarbonate, lipase, and chymotrypsin.
    • Stimulated secretion using secretin and caerulein in post-gastrectomy patients and controls.

    Main Results:

    • Significantly lower bicarbonate and lipase secretion observed in post-gastrectomy patients.
    • Reduced outputs: bicarbonate (47.9%), lipase (38.7%), chymotrypsin (24.2%).

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  • Steatorrhoea present in 67% of patients, with no correlation to lipase output.

    • Conclusions:

    • Exocrine pancreatic function is impaired in most patients post-total gastrectomy.
    • Bicarbonate and lipase secretion are particularly affected, showing mild to moderate impairment.