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Urolithiasis and hyperoxaluria in chronic inflammatory bowel disease
Scandinavian Journal of Gastroenterology
|January 1, 1979
Summary
This study found no increased incidence of urolithiasis in patients with hyperoxaluria and chronic inflammatory bowel disease compared to controls. Enteric hyperoxaluria may not be the primary cause of kidney stones in these patients.
Area of Science:
- Nephrology
- Gastroenterology
- Urology
Background:
- Chronic inflammatory bowel disease (IBD) is associated with an increased risk of urolithiasis.
- Enteric hyperoxaluria, elevated urinary oxalate, is often implicated in stone formation in IBD patients.
Purpose of the Study:
- To investigate the incidence of urolithiasis in patients with chronic IBD.
- To compare urolithiasis rates between hyperoxaluric and normo-oxaluric IBD patients.
- To evaluate the role of enteric hyperoxaluria in stone diathesis in IBD.
Main Methods:
- Studied 87 IBD patients on a standardized diet.
- Assessed renal oxalate excretion and urolithiasis incidence.
- Compared stone formation rates in hyperoxaluric versus normo-oxaluric groups.
- Analyzed urinary oxalate and calcium levels in stone-formers and non-stone-formers.
Main Results:
- Urolithiasis incidence was 35% in hyperoxaluric patients and 23% in normo-oxaluric patients (statistically insignificant difference).
- No significant difference in urinary oxalate or calcium between stone-formers and non-stone-formers.
- Oxalate was a more frequent component of calculi in normo-oxaluric patients.
Conclusions:
- An increased incidence of urolithiasis was not demonstrated in IBD patients with hyperoxaluria compared to controls.
- Results question the concept that enteric hyperoxaluria alone causes stone diathesis in chronic IBD.