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Post-hyperventilation apnoea in patients with brain damage.

S Jennett, K Ashbridge, J B North

    Journal of Neurology, Neurosurgery, and Psychiatry
    |March 1, 1974
    PubMed
    Summary
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    Brief voluntary hyperventilation causes apnoea in patients with supramedullary lesions, but not healthy individuals. This apnoea links to drowsiness, not lesion severity or carbon dioxide levels.

    Area of Science:

    • Neurology
    • Respiratory Physiology

    Background:

    • Supramedullary lesions can affect respiratory control.
    • Hyperventilation is a known physiological challenge.

    Purpose of the Study:

    • To investigate the effect of voluntary hyperventilation on apnoea in patients with supramedullary lesions.
    • To compare these effects with healthy controls.

    Main Methods:

    • A study involving 100 subjects.
    • Induction of brief voluntary hyperventilation.
    • Assessment of apnoea occurrence.
    • Correlation analysis with lesion extent, drowsiness, and end-tidal carbon dioxide tension.

    Main Results:

    • Voluntary hyperventilation frequently induced apnoea in patients with supramedullary lesions.

    Related Experiment Videos

  • Healthy individuals did not experience apnoea under the same conditions.
  • Apnoea occurrence correlated with drowsiness, not the extent of the lesion.
  • No significant relationship was found between apnoea and reduced end-tidal carbon dioxide tension.

    • Conclusions:

    • Brief voluntary hyperventilation is a potential trigger for apnoea in individuals with supramedullary lesions.
    • Drowsiness is a more significant factor in hyperventilation-induced apnoea than lesion severity.
    • Respiratory challenges like hyperventilation may reveal subtle neurological deficits.