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Alcohol-induced Cushingoid syndrome.

R M Jordan, J M Jacobson, R L Young

    Southern Medical Journal
    |October 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Alcohol-induced cushingoid syndrome can cause abnormal cortisol levels. Discontinuing alcohol intake resolved these hormonal imbalances and physical symptoms in a patient with alcoholic liver disease.

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    Area of Science:

    • Endocrinology
    • Hepatology
    • Metabolic Disorders

    Background:

    • Alcoholic liver disease (ALD) is a significant cause of chronic liver damage.
    • Cushing's syndrome is characterized by prolonged exposure to high cortisol levels.
    • Alcohol-induced cushingoid syndrome represents a complex interplay between liver function and hormonal regulation.

    Observation:

    • A 35-year-old woman with diagnosed alcoholic liver disease exhibited classic physical signs of Cushing's syndrome.
    • Laboratory tests confirmed hypercortisolism, with elevated urinary free cortisol and abnormal 17-hydroxycorticosteroid levels.
    • The patient's clinical presentation suggested a potential link between alcohol consumption and Cushing's syndrome.

    Findings:

    • Upon cessation of alcohol intake, the patient's Cushing's syndrome symptoms and physical stigmata progressively resolved.

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  • Biochemical markers of hypercortisolism normalized, including urinary free cortisol and the 17-hydroxycorticosteroid response to dexamethasone.
  • These results indicate that alcohol cessation is an effective intervention for alcohol-induced cushingoid syndrome.

    • Implications:

    • This case expands the understanding of glucocorticoid dysregulation in alcohol-related liver disease.
    • It highlights the importance of considering alcohol-induced cushingoid syndrome in patients with ALD and Cushingoid features.
    • The findings underscore the potential for reversibility of hormonal derangements with alcohol abstinence.