Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serial pulmonary function tests in progressive systemic sclerosis.

L R Bagg, D T Hughes

    Thorax
    |April 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Refining the Definitions of Biochemical and Clinical Cure for Primary Aldosteronism Using the Primary Aldosteronism Surgical Outcome (PASO) Classification System.

    World journal of surgery·2017
    Same author

    Some fundamental considerations in human population cytogenetics.

    The Eugenics review·2011
    Same author

    Acyl-homoserine-lactone autoinducer in the gastrointestinal [corrected] tract of feedlot cattle and correlation to season, E. coli O157:H7 prevalence, and diet.

    Current microbiology·2008
    Same author

    The role of chromosomes in the characterisation of human neoplasms. 1965.

    European journal of cancer (Oxford, England : 1990)·2004
    Same author

    Molecular analysis of drug resistant TB.

    Thorax·2002
    Same author

    Tuberculosis in an area bordering east London: significant local variations when compared to national data.

    Infection·2000

    Pulmonary function tests in systemic sclerosis reveal early impairment, often affecting lung transfer factor. Despite disease progression, lung involvement did not always predict a poor prognosis.

    Area of Science:

    • Pulmonary Medicine
    • Rheumatology
    • Systemic Sclerosis Research

    Background:

    • Progressive systemic sclerosis (PSS) can affect multiple organs, including the lungs.
    • Pulmonary involvement is a significant concern in PSS, impacting patient morbidity and mortality.

    Purpose of the Study:

    • To investigate the longitudinal changes in pulmonary function in patients with progressive systemic sclerosis.
    • To identify the earliest pulmonary function abnormalities and their relationship to disease progression and prognosis.

    Main Methods:

    • Serial pulmonary function tests were conducted over a mean of ten years.
    • Nine patients diagnosed with progressive systemic sclerosis were included in the study.

    Main Results:

    Related Experiment Videos

    • Pulmonary function abnormalities developed both early and late in the disease course.
    • Impairment of the transfer factor was the earliest observed abnormality.
    • All patients showed deterioration in some aspect of pulmonary function, with restriction or air trapping observed equally.

    Conclusions:

    • Pulmonary function abnormalities are common and progressive in systemic sclerosis.
    • Early detection of lung involvement, particularly transfer factor impairment, is crucial.
    • Pulmonary involvement in systemic sclerosis does not necessarily correlate with a poor prognosis, even with early onset.