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Related Experiment Videos

Heparin therapy: a simpler test of control.

A J Handley

    Journal of Clinical Pathology
    |March 1, 1974
    PubMed
    Summary

    A new bedside test accurately measures heparin activity, correlating well with existing methods. This whole blood activated partial thromboplastin time offers practical advantages for patient anticoagulation monitoring.

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    Area of Science:

    • Clinical Chemistry
    • Hematology
    • Pharmacology

    Background:

    • Anticoagulation therapy with heparin requires regular monitoring.
    • Existing methods for monitoring heparin activity can be time-consuming or complex.
    • There is a need for rapid, reliable bedside tests for heparin monitoring.

    Purpose of the Study:

    • To evaluate a bedside test for assessing heparin activity.
    • To compare the bedside test with the established whole blood clotting time.
    • To determine the clinical utility of the new test in anticoagulation management.

    Main Methods:

    • Assessed heparin activity using a bedside activated partial thromboplastin time test.
    • Performed testing during the clinical control of anticoagulation.
    • Correlated results with the whole blood clotting time.

    Main Results:

    • The bedside activated partial thromboplastin time showed a close correlation (r = 0.94) with the whole blood clotting time.
    • The test demonstrated several practical advantages over the whole blood clotting time.

    Conclusions:

    • The bedside activated partial thromboplastin time is a reliable and advantageous method for monitoring heparin activity.
    • This test can facilitate effective clinical control of anticoagulation at the patient's bedside.

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