Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selection for blood pressure levels in mice.

G Schlager

    Genetics
    |March 1, 1974
    PubMed
    Summary

    Systolic blood pressure selection showed immediate response, with distinct High and Low lines by generation 12. Genetic analysis revealed additive and dominance components in blood pressure inheritance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Computer-assisted skin cancer diagnosis : Is it time for artificial intelligence in clinical practice?]

    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2020
    Same author

    [Oral vs. enteral nutrition for patients with postoperative pancreatic fistula].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2019
    Same author

    [Preoperative diet reduces blood loss after liver surgery].

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2019
    Same author

    Cord blood-derived stem cells administered intravenously to newborn rats can engraft in brain and skin lesions and produce neuronal or epithelial progenitor cells.

    Journal of stem cells & regenerative medicine·2014
    Same author

    Catecholamine storage vesicle protein expression in genetic hypertension.

    Blood pressure·2000
    Same author

    Genome scan for blood pressure loci in mice.

    Hypertension (Dallas, Tex. : 1979)·1999

    Area of Science:

    • Genetics
    • Physiology

    Background:

    • Systolic blood pressure (SBP) is a key cardiovascular risk factor.
    • Understanding the genetic basis of SBP is crucial for developing targeted interventions.

    Purpose of the Study:

    • To investigate the genetic architecture of systolic blood pressure through long-term selective breeding in a rodent model.
    • To identify the genetic components (additive and dominance) contributing to SBP variation.

    Main Methods:

    • Two-way selective breeding for high and low systolic blood pressure over 12 generations.
    • Statistical comparison of selected lines with a random control line.
    • Genetic analysis of F(1), F(2), and backcross generations to determine inheritance patterns.

    Main Results:

    • Immediate and continuous response to selection for SBP for approximately eight generations.
    • Significant divergence between High and Low lines by generation 12 (males: 38 mmHg, females: 39 mmHg) with minimal overlap.
    • Cessation of response attributed to natural selection (litter size in Low line), increased mortality (High line), and genetic bottleneck effects.
    • Significant additive and dominance genetic variance components identified for SBP inheritance.

    Conclusions:

    • Long-term selective breeding effectively created distinct genetic lines for high and low systolic blood pressure.
    • The study identified both additive and dominance genetic factors influencing systolic blood pressure.
    • Potential biological constraints and evolutionary pressures can limit the response to selective breeding.

    Related Experiment Videos