[In vitro humeral serum cytotoxic reactions in melanoma]

Humoral antitumor cytotoxins were found in most of assayed sera from melanoma patients. The patients' sera can cross-react in cytotoxic reactions in vitro with allogenic cell-targets of melanoma. The sera of healthy donors prove to be cytotoxic for melanoma cell-targets in vitro, the degree of their cytotoxicity being similar to that of autologous sera. The cytotoxic effect of melanoma patient sera (and of healthy donors) on the cells of the primary melanoma focus is found to be reliably higher than their cytotoxic effect on metastatic cells.